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The U.S. President's Emergency Plan for AIDS Relief (PEPFAR) is the U.S. Government initiative to help save the lives of those suffering from HIV/AIDS around the world.  This historic commitment is the largest by any nation to combat a single disease internationally, and PEPFAR investments also help alleviate suffering from other diseases across the global health spectrum.  PEPFAR is driven by a shared responsibility among donor and partner nations and others to make smart investments to save lives.  

The Office of the U.S. Global AIDS Coordinator manages PEPFAR. The Coordinator is appointed by the President and confirmed by the Senate to coordinate and oversee the U.S. global response to HIV/AIDS. The Coordinator reports directly to the Secretary of State.

  • Read posts about PEPFAR on the blog
  • Read posts about PEPFAR on DipNote, the U.S. State Department’s blog

Global Health Initiative

PEPFAR is the cornerstone and largest component of the U.S. President’s Global Health Initiative. With a special focus on improving the health of women, newborns and children, the Global Health Initiative’s goal is to save the greatest number of lives by increasing and building upon what works and, then, supporting countries as they work to improve the health of their own people.

PEPFAR's Targets for Fiscal Years 2010-2014


  • support the prevention of more than 12 million new HIV infections;
  • ensure that every partner country with a generalized epidemic  has both 80% coverage of testing for pregnant women at the national level, and 85% coverage of antiretroviral drug (ARV) prophylaxis and treatment, as indicated, of women found to be HIV-infected;
  • double the number of at-risk babies born HIV-free, from the 240,000 babies of HIV-positive mothers who were born HIV-negative during the first five years of PEPFAR;
  • in every partner country with a generalized epidemic, provide 100% of youth in PEPFAR prevention programs with comprehensive and correct knowledge of the ways HIV/AIDS is transmitted and ways to protect themselves, consistent with Millennium Development Goal indicators in this area.

Care, Support and Treatment

In FY 2011, PEPFAR reached 3.9 million with treatment, laying a foundation for heightened efforts. On World AIDS Day 2011, President Obama announced a historic increase in PEPFAR’s treatment goal:

By the end of 2013, PEPFAR will directly support more than 6 million people on antiretroviral treatment – two million more than our previous goal. Read about this commitment and other expanded efforts announced by the President in this fact sheet or view his remarks

  • provide direct support for more than 4 million people on treatment, more than doubling the number of people directly supported on treatment during the first five years of PEPFAR;
  • support care for more than 12 million people, including 5 million orphans and vulnerable children; and
  • ensure that every partner country with a generalized epidemic reaches a threshold of 65% coverage for early infant diagnosis at the national level, and testing of 80% of older children of HIV-positive mothers, with increased referrals and linkages to care and treatment.


  • support training and retention of more than 140,000 new health care workers to strengthen health systems;
  • in order to support country ownership, ensure that in each country with a major PEPFAR investment (greater than $5 million), the partner government leads efforts to evaluate and define needs and roles in the national response; and
  • ensure that in every partner country with a Partnership Framework, each country will change policies to address the larger structural conditions, such as gender-based violence, stigma, or low male partner involvement, which contribute to the spread of the epidemic.

Implementing Agencies

Learn about the U.S. government agencies that have come together in the common cause of turning the tide against the HIV/AIDS pandemic.


View information about PEPFAR-supported efforts and related resources in participating countries.

PEPFAR’s Program Results

Annually, PEPFAR reports on results achieved by its programs across the range of prevention, treatment and care programs.  Reflecting America’s commitment to saving lives affected by HIV/AIDS, PEPFAR is supporting countries in providing HIV prevention, treatment and care to their people.

  • The U.S. directly supported life-saving antiretroviral treatment for more than 3.9 million men, women and children worldwide as of September 30, 2011.  
  • PEPFAR directly supported HIV testing and counseling for more than 9.8 million pregnant women in fiscal year 2011. PEPFAR supported antiretroviral drug prophylaxis to prevent mother-to-child transmission for more than 660,000 of these women who tested positive for HIV, allowing approximately 200,000 infants to be born HIV-free.  
  • PEPFAR directly supported nearly 13 million people with care and support, including more than 4.1 million orphans and vulnerable children, in fiscal year 2011.  
  • PEPFAR directly supported HIV counseling and testing for more than 40 million people in fiscal year 2011, providing a critical entry point to prevention, treatment, and care.  
  • The U.S. is the first and largest donor to the Global Fund to Fight AIDS, Tuberculosis and Malaria. To date, the U.S. has provided more than $5.8 billion to the Fund. Of the estimated 6.6 million individuals in low- and middle-income countries who currently receive treatment, nearly 5.6 million receive support through PEPFAR bilateral programs, the Global Fund, or both.

Read more about the latest PEPFAR results in Using Science to Save Lives: Latest PEPFAR Results (PDF 607 KB).

Last revised: 01/28/2014